Like Fu said, I use Trend Micro and they offer a number of home security suites to choose from.
I did just read an article which compaired Microsoft Secuity Essentials (which is free by they way) to other anti-virus/anti-malware programs and it did just as well or better then the paid ones.
A great anti-malware program is Malwarebytes. The manual scan is free, or you can purchase the real-time background protector for $25 for a year. But the program doesn’t do anti-virus.
I’m in the process of building my new computer and I’m most likely going to go with Security Essentials and purchase Malwarebytes.